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Novel Therapies for Patients with Metastatic Prostate Cancer Part 1Cabazitaxel (Jevtana,去癌達)
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00:07
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Outline
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00:46
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In 2004 docetaxel &predsisone was established as the new standard of care for patients that progressed on ADT
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02:23
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Cabazitaxel (JEVTANA®): a next-generation taxane
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03:16
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Mode of action of Cabazitaxel
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04:03
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Cabazitaxel Preclinical Summary
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04:41
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Cabazitaxel in Second-line CRPCTROPIC Phase III Study
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05:35
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Primary Endpoint: Overall Survival Cabazitaxel prolong survival vs. mitoxantrone in p’t progressed on docetaxel
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06:07
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Secondary Endpoint:Cabazitaxel Significantly Improved PFS
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06:19
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Secondary Endpoints:Cabazitaxel Significantly Improved Tumor and PSA Endpoints
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06:41
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Cabazitaxel : Subgroup Analysis of Overall Survival
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07:26
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Patients with initial PSA flare during cabazitaxel therapy are good responders
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08:14
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Severe neutropenia during cabazitaxel treatment is associated with survival benefit in men with mCRPC: A post-hoc analysis of the TROPIC trial
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09:14
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Cabazitaxel: Main Adverse Events
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09:49
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Management of Select Adverse Events
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09:50
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Cabazitaxel Premedication
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10:04
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Management of Neutropenia*
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10:17
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Growth Factor Support
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10:47
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Comparison of Adverse Events TROPIC vs CUP/EAP
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11:08
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Slide 20
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11:25
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Slide 21
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11:40
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Slide 22
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11:48
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Cabazitaxel remains active in patients progressing after docetaxel followed by abiraterone
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12:13
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Efficacy of Cabazitaxel in CRPC is independent of the presence of AR-V7 in circulating tumor cells
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12:30
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Slide 25
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12:32
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Characteristics of phase III trials examining upfront docetaxel chemotherapy for mHSPC
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12:48
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Current Clinical Trials with docetaxel or Cabazitaxel
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12:51
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Treatment Landscape