-
00:00
1.
Bone-Targeting Agents in Prostate Cancer Care - One Thing That Is Underrated in Taiwan
-
00:52
2.
Drugs to be talked about
-
01:33
3.
Drugs to be talked about
-
02:47
4.
Outline
-
03:03
5.
Outline
-
03:05
6.
RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
-
03:54
7.
A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
-
03:55
8.
RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
-
04:12
9.
A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
-
04:39
10.
Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
-
05:02
11.
Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
-
05:37
12.
Outline
-
05:42
13.
Spectrum of Bone Disease in Prostate Cancer
-
06:19
14.
ADT-Associated Bone Loss
-
06:58
15.
ADT and Fractures
-
07:01
16.
Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
-
07:02
17.
ADT and Fractures
-
07:52
18.
Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
-
08:40
19.
Alendronate Increases BMD During GnRH Agonist Therapy
-
09:03
20.
Pamidronate IV Every 3 Mos
-
09:12
21.
Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
-
09:29
22.
Denosumab Increased BMD at All Skeletal Sites
-
09:54
23.
Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
-
09:58
24.
Outline
-
10:26
25.
Spectrum of Bone Disease in Prostate Cancer
-
10:38
26.
Consequences of Prostate Cancer Progression on Bone Metastasis
-
11:11
27.
Time to Bone Metastasis in Non-metastatic CRPC (M0)
-
11:32
28.
Relationship Between PSADT and Risk for Bone Metastasis or Death
-
12:04
29.
PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
-
12:18
30.
Denosumab in High-Risk M0 CRPC: BMFS
-
12:29
31.
Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
-
12:45
32.
Denosumab in High-Risk M0 CRPC: BMFS
-
12:49
33.
Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
-
13:02
34.
Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
-
13:20
35.
Outline
-
13:22
36.
Spectrum of Bone Disease in Prostate Cancer
-
13:38
37.
Skeletal-Related Events and Clinical Consequences of Bone Metastases
-
14:07
38.
Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
-
14:20
39.
PR05: Symptomatic Bone PFS
-
14:57
40.
Time to First SRE: Zoledronate vs Placebo
-
15:31
41.
Zoledronic Acid Studies Primary Endpoint: SRE
-
15:51
42.
Time to First On-Study SRE: Denosumab vs Zoledronic Acid
-
16:06
43.
Zoledronic Acid Studies Primary Endpoint: SRE
-
16:07
44.
Time to First SRE: Zoledronate vs Placebo
-
16:08
45.
Zoledronic Acid Studies Primary Endpoint: SRE
-
16:08
46.
Time to First On-Study SRE: Denosumab vs Zoledronic Acid
-
16:39
47.
Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
-
17:09
48.
ALSYMPCA: Overall Survival
-
17:50
49.
Outline
-
17:54
50.
Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
-
18:34
51.
Preventing and Managing Hypocalcaemia
-
19:48
52.
藥物使用前的評估 是否能接受BPs或Dmab的使用?
-
21:21
53.
藥物使用中 如何預防顎骨壞死的產生?
-
21:51
54.
Outline
-
21:55
55.
Bone-Targeting Agents in Taiwan
-
22:38
56.
Guidelines for Management of Bone Metastases in Prostate Cancer
-
23:30
57.
Outline
-
23:32
58.
Incremental benefits of bone resorption inhibitors
-
24:36
59.
Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
-
26:08
60.
Thank you for your attention!
-
26:45
61.
Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
-
26:46
62.
Incremental benefits of bone resorption inhibitors
-
26:46
63.
Outline
-
26:47
64.
Guidelines for Management of Bone Metastases in Prostate Cancer
-
26:47
65.
Bone-Targeting Agents in Taiwan
-
26:48
66.
Outline
-
26:48
67.
藥物使用中 如何預防顎骨壞死的產生?
-
26:48
68.
藥物使用前的評估 是否能接受BPs或Dmab的使用?
-
26:49
69.
Preventing and Managing Hypocalcaemia
-
26:49
70.
Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
-
26:53
71.
Outline
-
26:54
72.
ALSYMPCA: Overall Survival
-
26:54
73.
Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
-
26:55
74.
Time to First On-Study SRE: Denosumab vs Zoledronic Acid
-
26:55
75.
Zoledronic Acid Studies Primary Endpoint: SRE
-
27:07
76.
Time to First SRE: Zoledronate vs Placebo
-
29:39
77.
PR05: Symptomatic Bone PFS
-
29:39
78.
Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
-
29:40
79.
Skeletal-Related Events and Clinical Consequences of Bone Metastases
-
29:40
80.
Spectrum of Bone Disease in Prostate Cancer
-
29:41
81.
Outline
-
29:41
82.
Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
-
29:42
83.
Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
-
29:43
84.
Denosumab in High-Risk M0 CRPC: BMFS
-
29:43
85.
PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
-
29:44
86.
Relationship Between PSADT and Risk for Bone Metastasis or Death
-
29:44
87.
Time to Bone Metastasis in Non-metastatic CRPC (M0)
-
29:45
88.
Consequences of Prostate Cancer Progression on Bone Metastasis
-
29:45
89.
Spectrum of Bone Disease in Prostate Cancer
-
29:46
90.
Outline
-
29:46
91.
Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
-
29:47
92.
Denosumab Increased BMD at All Skeletal Sites
-
29:48
93.
Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
-
29:48
94.
Pamidronate IV Every 3 Mos
-
29:49
95.
Alendronate Increases BMD During GnRH Agonist Therapy
-
29:49
96.
Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
-
29:50
97.
ADT and Fractures
-
29:51
98.
ADT-Associated Bone Loss
-
29:51
99.
Spectrum of Bone Disease in Prostate Cancer
-
29:52
100.
Outline
-
29:53
101.
Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
-
29:54
102.
Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
-
29:54
103.
A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
-
29:55
104.
RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
-
29:55
105.
Outline
-
29:56
106.
Outline
-
29:57
107.
Drugs to be talked about