• 00:00 1.
    Bone-Targeting Agents in Prostate Cancer Care - One Thing That Is Underrated in Taiwan
  • 00:52 2.
    Drugs to be talked about
  • 01:33 3.
    Drugs to be talked about
  • 02:47 4.
    Outline
  • 03:03 5.
    Outline
  • 03:05 6.
    RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
  • 03:54 7.
    A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
  • 03:55 8.
    RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
  • 04:12 9.
    A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
  • 04:39 10.
    Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
  • 05:02 11.
    Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
  • 05:37 12.
    Outline
  • 05:42 13.
    Spectrum of Bone Disease in Prostate Cancer
  • 06:19 14.
    ADT-Associated Bone Loss
  • 06:58 15.
    ADT and Fractures
  • 07:01 16.
    Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
  • 07:02 17.
    ADT and Fractures
  • 07:52 18.
    Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
  • 08:40 19.
    Alendronate Increases BMD During GnRH Agonist Therapy
  • 09:03 20.
    Pamidronate IV Every 3 Mos
  • 09:12 21.
    Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
  • 09:29 22.
    Denosumab Increased BMD at All Skeletal Sites
  • 09:54 23.
    Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
  • 09:58 24.
    Outline
  • 10:26 25.
    Spectrum of Bone Disease in Prostate Cancer
  • 10:38 26.
    Consequences of Prostate Cancer Progression on Bone Metastasis
  • 11:11 27.
    Time to Bone Metastasis in Non-metastatic CRPC (M0)
  • 11:32 28.
    Relationship Between PSADT and Risk for Bone Metastasis or Death
  • 12:04 29.
    PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
  • 12:18 30.
    Denosumab in High-Risk M0 CRPC: BMFS
  • 12:29 31.
    Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
  • 12:45 32.
    Denosumab in High-Risk M0 CRPC: BMFS
  • 12:49 33.
    Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
  • 13:02 34.
    Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
  • 13:20 35.
    Outline
  • 13:22 36.
    Spectrum of Bone Disease in Prostate Cancer
  • 13:38 37.
    Skeletal-Related Events and Clinical Consequences of Bone Metastases
  • 14:07 38.
    Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
  • 14:20 39.
    PR05: Symptomatic Bone PFS
  • 14:57 40.
    Time to First SRE: Zoledronate vs Placebo
  • 15:31 41.
    Zoledronic Acid Studies Primary Endpoint: SRE
  • 15:51 42.
    Time to First On-Study SRE: Denosumab vs Zoledronic Acid
  • 16:06 43.
    Zoledronic Acid Studies Primary Endpoint: SRE
  • 16:07 44.
    Time to First SRE: Zoledronate vs Placebo
  • 16:08 45.
    Zoledronic Acid Studies Primary Endpoint: SRE
  • 16:08 46.
    Time to First On-Study SRE: Denosumab vs Zoledronic Acid
  • 16:39 47.
    Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
  • 17:09 48.
    ALSYMPCA: Overall Survival
  • 17:50 49.
    Outline
  • 17:54 50.
    Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
  • 18:34 51.
    Preventing and Managing Hypocalcaemia
  • 19:48 52.
    藥物使用前的評估 是否能接受BPs或Dmab的使用?
  • 21:21 53.
    藥物使用中 如何預防顎骨壞死的產生?
  • 21:51 54.
    Outline
  • 21:55 55.
    Bone-Targeting Agents in Taiwan
  • 22:38 56.
    Guidelines for Management of Bone Metastases in Prostate Cancer
  • 23:30 57.
    Outline
  • 23:32 58.
    Incremental benefits of bone resorption inhibitors
  • 24:36 59.
    Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
  • 26:08 60.
    Thank you for your attention!
  • 26:45 61.
    Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
  • 26:46 62.
    Incremental benefits of bone resorption inhibitors
  • 26:46 63.
    Outline
  • 26:47 64.
    Guidelines for Management of Bone Metastases in Prostate Cancer
  • 26:47 65.
    Bone-Targeting Agents in Taiwan
  • 26:48 66.
    Outline
  • 26:48 67.
    藥物使用中 如何預防顎骨壞死的產生?
  • 26:48 68.
    藥物使用前的評估 是否能接受BPs或Dmab的使用?
  • 26:49 69.
    Preventing and Managing Hypocalcaemia
  • 26:49 70.
    Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
  • 26:53 71.
    Outline
  • 26:54 72.
    ALSYMPCA: Overall Survival
  • 26:54 73.
    Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
  • 26:55 74.
    Time to First On-Study SRE: Denosumab vs Zoledronic Acid
  • 26:55 75.
    Zoledronic Acid Studies Primary Endpoint: SRE
  • 27:07 76.
    Time to First SRE: Zoledronate vs Placebo
  • 29:39 77.
    PR05: Symptomatic Bone PFS
  • 29:39 78.
    Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
  • 29:40 79.
    Skeletal-Related Events and Clinical Consequences of Bone Metastases
  • 29:40 80.
    Spectrum of Bone Disease in Prostate Cancer
  • 29:41 81.
    Outline
  • 29:41 82.
    Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
  • 29:42 83.
    Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
  • 29:43 84.
    Denosumab in High-Risk M0 CRPC: BMFS
  • 29:43 85.
    PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
  • 29:44 86.
    Relationship Between PSADT and Risk for Bone Metastasis or Death
  • 29:44 87.
    Time to Bone Metastasis in Non-metastatic CRPC (M0)
  • 29:45 88.
    Consequences of Prostate Cancer Progression on Bone Metastasis
  • 29:45 89.
    Spectrum of Bone Disease in Prostate Cancer
  • 29:46 90.
    Outline
  • 29:46 91.
    Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
  • 29:47 92.
    Denosumab Increased BMD at All Skeletal Sites
  • 29:48 93.
    Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
  • 29:48 94.
    Pamidronate IV Every 3 Mos
  • 29:49 95.
    Alendronate Increases BMD During GnRH Agonist Therapy
  • 29:49 96.
    Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
  • 29:50 97.
    ADT and Fractures
  • 29:51 98.
    ADT-Associated Bone Loss
  • 29:51 99.
    Spectrum of Bone Disease in Prostate Cancer
  • 29:52 100.
    Outline
  • 29:53 101.
    Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
  • 29:54 102.
    Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
  • 29:54 103.
    A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
  • 29:55 104.
    RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
  • 29:55 105.
    Outline
  • 29:56 106.
    Outline
  • 29:57 107.
    Drugs to be talked about
  • 索引
  • 筆記
  • 討論
  • 全螢幕
Bone‐Targeting Agents in Prostate Cancer Care– One Thing That is Underrated in Taiwan
長度: 32:21, 瀏覽: 821, 最近修訂: 2017-05-19
    • 00:00 1.
      Bone-Targeting Agents in Prostate Cancer Care - One Thing That Is Underrated in Taiwan
    • 00:52 2.
      Drugs to be talked about
    • 01:33 3.
      Drugs to be talked about
    • 02:47 4.
      Outline
    • 03:03 5.
      Outline
    • 03:05 6.
      RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
    • 03:54 7.
      A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
    • 03:55 8.
      RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
    • 04:12 9.
      A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
    • 04:39 10.
      Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
    • 05:02 11.
      Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
    • 05:37 12.
      Outline
    • 05:42 13.
      Spectrum of Bone Disease in Prostate Cancer
    • 06:19 14.
      ADT-Associated Bone Loss
    • 06:58 15.
      ADT and Fractures
    • 07:01 16.
      Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
    • 07:02 17.
      ADT and Fractures
    • 07:52 18.
      Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
    • 08:40 19.
      Alendronate Increases BMD During GnRH Agonist Therapy
    • 09:03 20.
      Pamidronate IV Every 3 Mos
    • 09:12 21.
      Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
    • 09:29 22.
      Denosumab Increased BMD at All Skeletal Sites
    • 09:54 23.
      Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
    • 09:58 24.
      Outline
    • 10:26 25.
      Spectrum of Bone Disease in Prostate Cancer
    • 10:38 26.
      Consequences of Prostate Cancer Progression on Bone Metastasis
    • 11:11 27.
      Time to Bone Metastasis in Non-metastatic CRPC (M0)
    • 11:32 28.
      Relationship Between PSADT and Risk for Bone Metastasis or Death
    • 12:04 29.
      PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
    • 12:18 30.
      Denosumab in High-Risk M0 CRPC: BMFS
    • 12:29 31.
      Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
    • 12:45 32.
      Denosumab in High-Risk M0 CRPC: BMFS
    • 12:49 33.
      Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
    • 13:02 34.
      Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
    • 13:20 35.
      Outline
    • 13:22 36.
      Spectrum of Bone Disease in Prostate Cancer
    • 13:38 37.
      Skeletal-Related Events and Clinical Consequences of Bone Metastases
    • 14:07 38.
      Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
    • 14:20 39.
      PR05: Symptomatic Bone PFS
    • 14:57 40.
      Time to First SRE: Zoledronate vs Placebo
    • 15:31 41.
      Zoledronic Acid Studies Primary Endpoint: SRE
    • 15:51 42.
      Time to First On-Study SRE: Denosumab vs Zoledronic Acid
    • 16:06 43.
      Zoledronic Acid Studies Primary Endpoint: SRE
    • 16:07 44.
      Time to First SRE: Zoledronate vs Placebo
    • 16:08 45.
      Zoledronic Acid Studies Primary Endpoint: SRE
    • 16:08 46.
      Time to First On-Study SRE: Denosumab vs Zoledronic Acid
    • 16:39 47.
      Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
    • 17:09 48.
      ALSYMPCA: Overall Survival
    • 17:50 49.
      Outline
    • 17:54 50.
      Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
    • 18:34 51.
      Preventing and Managing Hypocalcaemia
    • 19:48 52.
      藥物使用前的評估 是否能接受BPs或Dmab的使用?
    • 21:21 53.
      藥物使用中 如何預防顎骨壞死的產生?
    • 21:51 54.
      Outline
    • 21:55 55.
      Bone-Targeting Agents in Taiwan
    • 22:38 56.
      Guidelines for Management of Bone Metastases in Prostate Cancer
    • 23:30 57.
      Outline
    • 23:32 58.
      Incremental benefits of bone resorption inhibitors
    • 24:36 59.
      Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
    • 26:08 60.
      Thank you for your attention!
    • 26:45 61.
      Summary of Phase III Trials Investigating the Use of Antiresorptive Drugs
    • 26:46 62.
      Incremental benefits of bone resorption inhibitors
    • 26:46 63.
      Outline
    • 26:47 64.
      Guidelines for Management of Bone Metastases in Prostate Cancer
    • 26:47 65.
      Bone-Targeting Agents in Taiwan
    • 26:48 66.
      Outline
    • 26:48 67.
      藥物使用中 如何預防顎骨壞死的產生?
    • 26:48 68.
      藥物使用前的評估 是否能接受BPs或Dmab的使用?
    • 26:49 69.
      Preventing and Managing Hypocalcaemia
    • 26:49 70.
      Characteristics of Antiresorptive Agents Used for Patients with Prostate Cancer
    • 26:53 71.
      Outline
    • 26:54 72.
      ALSYMPCA: Overall Survival
    • 26:54 73.
      Denosumab vs ZOL in CRPC: No Effect on Overall Disease Progression and Survival
    • 26:55 74.
      Time to First On-Study SRE: Denosumab vs Zoledronic Acid
    • 26:55 75.
      Zoledronic Acid Studies Primary Endpoint: SRE
    • 27:07 76.
      Time to First SRE: Zoledronate vs Placebo
    • 29:39 77.
      PR05: Symptomatic Bone PFS
    • 29:39 78.
      Bone Metastases Can result in Serious and Debilitating Skeletal-Related Events (SREs)
    • 29:40 79.
      Skeletal-Related Events and Clinical Consequences of Bone Metastases
    • 29:40 80.
      Spectrum of Bone Disease in Prostate Cancer
    • 29:41 81.
      Outline
    • 29:41 82.
      Bone Metastasis–Free Survival in Patients With PSADT ≤ 4 Mos
    • 29:42 83.
      Bone Metastasis–Free Survival in Patients With PSADT ≤ 6 Mos
    • 29:43 84.
      Denosumab in High-Risk M0 CRPC: BMFS
    • 29:43 85.
      PR04: Time to Symptomatic Bone Metastases or Prostate Cancer Death
    • 29:44 86.
      Relationship Between PSADT and Risk for Bone Metastasis or Death
    • 29:44 87.
      Time to Bone Metastasis in Non-metastatic CRPC (M0)
    • 29:45 88.
      Consequences of Prostate Cancer Progression on Bone Metastasis
    • 29:45 89.
      Spectrum of Bone Disease in Prostate Cancer
    • 29:46 90.
      Outline
    • 29:46 91.
      Denosumab for Fracture Prevention in Early-Stage Prostate Cancer
    • 29:47 92.
      Denosumab Increased BMD at All Skeletal Sites
    • 29:48 93.
      Annual Zoledronic Acid Increases BMD During GnRH Agonist Therapy
    • 29:48 94.
      Pamidronate IV Every 3 Mos
    • 29:49 95.
      Alendronate Increases BMD During GnRH Agonist Therapy
    • 29:49 96.
      Higher Death Rate Observed at 36 Mos in Pts With Vertebral Fracture at Study Entry
    • 29:50 97.
      ADT and Fractures
    • 29:51 98.
      ADT-Associated Bone Loss
    • 29:51 99.
      Spectrum of Bone Disease in Prostate Cancer
    • 29:52 100.
      Outline
    • 29:53 101.
      Denosumab Inhibits RANK Ligand to Interrupt the ‘Vicious Cycle’ of Bone Destruction
    • 29:54 102.
      Bisphosphonates Embed in Bone And Induce Apoptosis of Activated Osteoclasts
    • 29:54 103.
      A Vicious Cycle of Bone Destruction May Develop in the Presence of Tumour Cells
    • 29:55 104.
      RANK Ligand Is An Essential Mediator of Osteoclast Formation, Function and Survival
    • 29:55 105.
      Outline
    • 29:56 106.
      Outline
    • 29:57 107.
      Drugs to be talked about
    位置
    資料夾名稱
    2015臺大攝護祭-醫藥護人員場
    發表人
    系統管理者
    單位
    泌尿部
    建立
    2017-05-19 16:56:16
    最近修訂
    2017-05-19 18:59:21
    長度
    32:21