• 00:00 1.
    Reappraisal of Published Randomized LUTS/BPH Clinical Trials –What Have We Learned and Where Do We Stand?
  • 02:37 2.
    Dr. Charles Sydney Burwell, Dean, Harvard Medical School 1935-49
  • 03:56 3.
    請問蒲永孝教授講話比較有公信力還是王炯珵醫師?
  • 04:29 4.
    Slide 4
  • 05:48 5.
    Guidelines Include Algorithms to Illustrate Medical Treatment Choices According to Evidence-based Medicine and Patients’ Profiles
  • 06:04 6.
    Recommendations for Treatment of Men with BPH Have Evolved in Line With Available Clinical Evidence
  • 06:49 7.
    VACOOP study
  • 07:54 8.
    ALFIN Study
  • 09:20 9.
    What does the guidelines recommend?
  • 10:01 10.
    PREDICT study
  • 10:56 11.
    What does the guidelines recommend?
  • 10:57 12.
    PREDICT study
  • 11:21 13.
    MTOPS Study
  • 13:30 14.
    Guideline Update
  • 14:04 15.
    Learning From Clinical Trial Experience
  • 14:26 16.
    Prostate volume: Higher Baseline PV Associated With an Increase in BPH Progression Events in MTOPS
  • 15:20 17.
    PSA: Higher Baseline PSA Associated With an Increase in BPH Progression Events in MTOPS
  • 16:01 18.
    CombAT study is Designed to Investigate the Efficacy and Safety of Combination Therapy in Men with m-s Symptoms of BPH and at Risk of Clinical Progression
  • 17:02 19.
    CombAT Study
  • 18:14 20.
    Combination Therapy Significantly Reduces the Relative Risk of AUR and/or BPH-related Surgery at 4 years
  • 18:49 21.
    Combination Therapy Reduces Risk of AUR, BPH-related Surgery and BPH Clinical Progression
  • 19:27 22.
    Dutasteride Plus Tamsulosin Provided Significantly Greater Symptom Benefit Than Either Monotherapy
  • 20:16 23.
    Drug Adherence
  • 21:23 24.
    Choose the Right Population for Study
  • 21:47 25.
    Entry Criteria for CombAT Included a BPH Population at Higher Risk of Progression Than MTOPS
  • 22:54 26.
    Differences between MTOPS and CombAT in the population under study
  • 23:55 27.
    Long-term Benefit of 5-ARI and α1-Blocker Combination Therapy1,2,3
  • 25:09 28.
    Slide 26
  • 26:11 29.
    Create More Benefits by Designing Following Study to Fill the Data Gap
  • 26:28 30.
    Understanding the Study Patient Populations
  • 26:59 31.
    Rationale for the CONDUCT StudyAdds to existing evidence
  • 27:43 32.
    CONDUCT: Study Design
  • 27:58 33.
    CONDUCT 最偉大的地方: 30min衛教
  • 29:29 34.
    Slide 32
  • 30:08 35.
    Efficacy: Mean IPSS at Each Visit
  • 30:28 36.
    Study Results: IPSS Change
  • 30:45 37.
    Efficacy: BPH Clinical Progression1
  • 30:59 38.
    CONDUCT Results: Summary1,2
  • 31:15 39.
    Dig Out Useful Evidence Beyond Studies by Post-hoc Analysis
  • 31:26 40.
    5ARI Prostate Cancer Risk Reduction Studies
  • 32:30 41.
    Slide 39
  • 32:50 42.
    Slide 40
  • 34:24 43.
    Slide 41
  • 35:07 44.
    Take Home Messages
  • 35:09 45.
    Slide 41
  • 35:40 46.
    Take Home Messages
  • 索引
  • 筆記
  • 討論
  • 全螢幕
Reappraisal of Published Randomized LUTS/BPH Clinical Trials–What Have We Learned and Where Do We Stand?
長度: 38:16, 瀏覽: 772, 最近修訂: 2017-05-19
    • 00:00 1.
      Reappraisal of Published Randomized LUTS/BPH Clinical Trials –What Have We Learned and Where Do We Stand?
    • 02:37 2.
      Dr. Charles Sydney Burwell, Dean, Harvard Medical School 1935-49
    • 03:56 3.
      請問蒲永孝教授講話比較有公信力還是王炯珵醫師?
    • 04:29 4.
      Slide 4
    • 05:48 5.
      Guidelines Include Algorithms to Illustrate Medical Treatment Choices According to Evidence-based Medicine and Patients’ Profiles
    • 06:04 6.
      Recommendations for Treatment of Men with BPH Have Evolved in Line With Available Clinical Evidence
    • 06:49 7.
      VACOOP study
    • 07:54 8.
      ALFIN Study
    • 09:20 9.
      What does the guidelines recommend?
    • 10:01 10.
      PREDICT study
    • 10:56 11.
      What does the guidelines recommend?
    • 10:57 12.
      PREDICT study
    • 11:21 13.
      MTOPS Study
    • 13:30 14.
      Guideline Update
    • 14:04 15.
      Learning From Clinical Trial Experience
    • 14:26 16.
      Prostate volume: Higher Baseline PV Associated With an Increase in BPH Progression Events in MTOPS
    • 15:20 17.
      PSA: Higher Baseline PSA Associated With an Increase in BPH Progression Events in MTOPS
    • 16:01 18.
      CombAT study is Designed to Investigate the Efficacy and Safety of Combination Therapy in Men with m-s Symptoms of BPH and at Risk of Clinical Progression
    • 17:02 19.
      CombAT Study
    • 18:14 20.
      Combination Therapy Significantly Reduces the Relative Risk of AUR and/or BPH-related Surgery at 4 years
    • 18:49 21.
      Combination Therapy Reduces Risk of AUR, BPH-related Surgery and BPH Clinical Progression
    • 19:27 22.
      Dutasteride Plus Tamsulosin Provided Significantly Greater Symptom Benefit Than Either Monotherapy
    • 20:16 23.
      Drug Adherence
    • 21:23 24.
      Choose the Right Population for Study
    • 21:47 25.
      Entry Criteria for CombAT Included a BPH Population at Higher Risk of Progression Than MTOPS
    • 22:54 26.
      Differences between MTOPS and CombAT in the population under study
    • 23:55 27.
      Long-term Benefit of 5-ARI and α1-Blocker Combination Therapy1,2,3
    • 25:09 28.
      Slide 26
    • 26:11 29.
      Create More Benefits by Designing Following Study to Fill the Data Gap
    • 26:28 30.
      Understanding the Study Patient Populations
    • 26:59 31.
      Rationale for the CONDUCT StudyAdds to existing evidence
    • 27:43 32.
      CONDUCT: Study Design
    • 27:58 33.
      CONDUCT 最偉大的地方: 30min衛教
    • 29:29 34.
      Slide 32
    • 30:08 35.
      Efficacy: Mean IPSS at Each Visit
    • 30:28 36.
      Study Results: IPSS Change
    • 30:45 37.
      Efficacy: BPH Clinical Progression1
    • 30:59 38.
      CONDUCT Results: Summary1,2
    • 31:15 39.
      Dig Out Useful Evidence Beyond Studies by Post-hoc Analysis
    • 31:26 40.
      5ARI Prostate Cancer Risk Reduction Studies
    • 32:30 41.
      Slide 39
    • 32:50 42.
      Slide 40
    • 34:24 43.
      Slide 41
    • 35:07 44.
      Take Home Messages
    • 35:09 45.
      Slide 41
    • 35:40 46.
      Take Home Messages
    位置
    資料夾名稱
    2015臺大攝護祭-醫藥護人員場
    發表人
    系統管理者
    單位
    泌尿部
    建立
    2017-05-19 17:14:21
    最近修訂
    2017-05-19 19:40:04
    長度
    38:16