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00:00
1.
Reappraisal of Published Randomized LUTS/BPH Clinical Trials –What Have We Learned and Where Do We Stand?
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02:37
2.
Dr. Charles Sydney Burwell, Dean, Harvard Medical School 1935-49
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03:56
3.
請問蒲永孝教授講話比較有公信力還是王炯珵醫師?
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04:29
4.
Slide 4
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05:48
5.
Guidelines Include Algorithms to Illustrate Medical Treatment Choices According to Evidence-based Medicine and Patients’ Profiles
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06:04
6.
Recommendations for Treatment of Men with BPH Have Evolved in Line With Available Clinical Evidence
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06:49
7.
VACOOP study
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07:54
8.
ALFIN Study
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09:20
9.
What does the guidelines recommend?
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10:01
10.
PREDICT study
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10:56
11.
What does the guidelines recommend?
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10:57
12.
PREDICT study
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11:21
13.
MTOPS Study
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13:30
14.
Guideline Update
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14:04
15.
Learning From Clinical Trial Experience
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14:26
16.
Prostate volume: Higher Baseline PV Associated With an Increase in BPH Progression Events in MTOPS
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15:20
17.
PSA: Higher Baseline PSA Associated With an Increase in BPH Progression Events in MTOPS
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16:01
18.
CombAT study is Designed to Investigate the Efficacy and Safety of Combination Therapy in Men with m-s Symptoms of BPH and at Risk of Clinical Progression
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17:02
19.
CombAT Study
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18:14
20.
Combination Therapy Significantly Reduces the Relative Risk of AUR and/or BPH-related Surgery at 4 years
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18:49
21.
Combination Therapy Reduces Risk of AUR, BPH-related Surgery and BPH Clinical Progression
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19:27
22.
Dutasteride Plus Tamsulosin Provided Significantly Greater Symptom Benefit Than Either Monotherapy
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20:16
23.
Drug Adherence
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21:23
24.
Choose the Right Population for Study
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21:47
25.
Entry Criteria for CombAT Included a BPH Population at Higher Risk of Progression Than MTOPS
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22:54
26.
Differences between MTOPS and CombAT in the population under study
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23:55
27.
Long-term Benefit of 5-ARI and α1-Blocker Combination Therapy1,2,3
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25:09
28.
Slide 26
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26:11
29.
Create More Benefits by Designing Following Study to Fill the Data Gap
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26:28
30.
Understanding the Study Patient Populations
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26:59
31.
Rationale for the CONDUCT StudyAdds to existing evidence
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27:43
32.
CONDUCT: Study Design
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27:58
33.
CONDUCT 最偉大的地方: 30min衛教
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29:29
34.
Slide 32
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30:08
35.
Efficacy: Mean IPSS at Each Visit
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30:28
36.
Study Results: IPSS Change
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30:45
37.
Efficacy: BPH Clinical Progression1
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30:59
38.
CONDUCT Results: Summary1,2
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31:15
39.
Dig Out Useful Evidence Beyond Studies by Post-hoc Analysis
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31:26
40.
5ARI Prostate Cancer Risk Reduction Studies
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32:30
41.
Slide 39
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32:50
42.
Slide 40
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34:24
43.
Slide 41
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35:07
44.
Take Home Messages
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35:09
45.
Slide 41
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35:40
46.
Take Home Messages