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00:00
1.
Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
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00:56
2.
Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
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01:01
3.
什麼是mCRPC? 和HRPC有何不同?
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01:20
4.
HRPC versus CRPC
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02:23
5.
Prostate Cancer Disease Stages<br />
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03:15
6.
去勢療法出現抗性的攝護腺癌(CRPC)
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03:37
7.
去勢療法出現抗性的攝護腺癌(CRPC)
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04:26
8.
Molecular States Framework for AR Activation in Prostate Cancer
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04:49
9.
Molecular States Framework for AR Activation in Prostate Cancer
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05:34
10.
對於mCRPC,目前有哪些新藥?作用機轉為何?
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05:49
11.
Approved New Drugs for mCRPC
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06:39
12.
Approved New Drugs for mCRPC
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07:02
13.
1966年諾貝爾醫學獎得主
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07:21
14.
傳統上賀爾蒙治療的策略
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08:22
15.
mCRPC病人賀爾蒙治療的策略
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09:07
16.
正常情況下雄性素分泌的比例
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09:23
17.
去勢男性雄性素分泌的情形
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09:52
18.
Sites of Action by Androgen Biosynthesis Inhibitors
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10:34
19.
<br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
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10:39
20.
<br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
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11:18
21.
Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
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11:22
22.
Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
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12:35
23.
Radium-223 Is a Unique α-Emitter
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13:05
24.
[TITLE]
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14:14
25.
Principle of Sipuleucel-T
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15:40
26.
這些新藥能延長生命嗎? 能減輕痛苦嗎?
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15:52
27.
Androgen-Deprivation Therapy雄性素去除療法:Continuous androgen deprivation (pharmaceutical or surgical) should be continued indefinitely regardless of additional therapies(Therapies in Addition to Androgen-Deprivation Therapy)Therapies with demonstrated survival
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16:41
28.
Therapies with demonstrated survival benefit and unclear quality-of-life benefit可延長存活期:Sipuleucel-T in asymptomatic or minimally symptomatic p’tCabazitaxel in p’t progressed after docetaxelTherapies with quality-of-life benefit without demonstrated surviv
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17:47
29.
Therapies without demonstrated survival or quality-of-life benefit過去臨床試驗證實無效者:BevacizumabEstramustineSunitinibPalliative Care Services緩和醫療Palliative care should be offered to all patients, particularly to those exhibiting symptoms or quality-of-life (QOL)
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18:27
30.
New Drugs for Patient with mCRPC after Docetaxel
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19:08
31.
New Drugs for Patients with Chemo-naive mCRPC
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19:31
32.
這些新藥國內已經上市了嗎? 健保的給付規定?怎麼用呢?
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19:41
33.
Approved New Drugs for mCRPC
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20:35
34.
Docetaxel : 健保規定
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20:53
35.
Abiraterone : 健保規定
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21:39
36.
Docetaxel的副作用
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22:52
37.
Abiraterone(澤珂)的建議劑量及服藥方式
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23:24
38.
Hormone Concentration After Abiraterone Acetate
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24:03
39.
Hormone Concentration After Abiraterone Acetate + Dexamethasone
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24:33
40.
Abiraterone的副作用
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25:12
41.
臨床上如何選擇適合的mCRPC藥物?
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25:17
42.
Slide 38
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26:13
43.
Index Patient 3: Symptomatic mCRPC with good performance status and no prior docetaxel chemotherapy(有症狀,身體狀況良好,未接受過化療)
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26:46
44.
Slide 40
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26:47
45.
Index Patient 5: (Symptomatic) mCRPC with good performance status and prior docetaxel chemotherapy(有症狀,身體狀況良好,有接受過化療)
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27:30
46.
Slide 42
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27:33
47.
Index Patient 2: Asymptomatic or minimally-symptomatic mCRPC without prior docetaxel chemo(沒有症狀,身體狀況良好,沒有接受過化療)
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28:20
48.
Proposed Decision Tree forAsymptomatic mCRPC (Clinical factor)
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29:16
49.
Slide 45
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29:53
50.
Slide 46
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30:22
51.
Slide 47
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30:35
52.
Common Drug Combination in mCRPC
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31:52
53.
結論
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33:49
54.
結論