• 00:00 1.
    Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
  • 00:56 2.
    Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
  • 01:01 3.
    什麼是mCRPC? 和HRPC有何不同?
  • 01:20 4.
    HRPC versus CRPC
  • 02:23 5.
    Prostate Cancer Disease Stages<br />
  • 03:15 6.
    去勢療法出現抗性的攝護腺癌(CRPC)
  • 03:37 7.
    去勢療法出現抗性的攝護腺癌(CRPC)
  • 04:26 8.
    Molecular States Framework for AR Activation in Prostate Cancer
  • 04:49 9.
    Molecular States Framework for AR Activation in Prostate Cancer
  • 05:34 10.
    對於mCRPC,目前有哪些新藥?作用機轉為何?
  • 05:49 11.
    Approved New Drugs for mCRPC
  • 06:39 12.
    Approved New Drugs for mCRPC
  • 07:02 13.
    1966年諾貝爾醫學獎得主
  • 07:21 14.
    傳統上賀爾蒙治療的策略
  • 08:22 15.
    mCRPC病人賀爾蒙治療的策略
  • 09:07 16.
    正常情況下雄性素分泌的比例
  • 09:23 17.
    去勢男性雄性素分泌的情形
  • 09:52 18.
    Sites of Action by Androgen Biosynthesis Inhibitors
  • 10:34 19.
    <br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
  • 10:39 20.
    <br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
  • 11:18 21.
    Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
  • 11:22 22.
    Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
  • 12:35 23.
    Radium-223 Is a Unique α-Emitter
  • 13:05 24.
    [TITLE]
  • 14:14 25.
    Principle of Sipuleucel-T
  • 15:40 26.
    這些新藥能延長生命嗎? 能減輕痛苦嗎?
  • 15:52 27.
    Androgen-Deprivation Therapy雄性素去除療法:Continuous androgen deprivation (pharmaceutical or surgical) should be continued indefinitely regardless of additional therapies(Therapies in Addition to Androgen-Deprivation Therapy)Therapies with demonstrated survival
  • 16:41 28.
    Therapies with demonstrated survival benefit and unclear quality-of-life benefit可延長存活期:Sipuleucel-T in asymptomatic or minimally symptomatic p’tCabazitaxel in p’t progressed after docetaxelTherapies with quality-of-life benefit without demonstrated surviv
  • 17:47 29.
    Therapies without demonstrated survival or quality-of-life benefit過去臨床試驗證實無效者:BevacizumabEstramustineSunitinibPalliative Care Services緩和醫療Palliative care should be offered to all patients, particularly to those exhibiting symptoms or quality-of-life (QOL)
  • 18:27 30.
    New Drugs for Patient with mCRPC after Docetaxel
  • 19:08 31.
    New Drugs for Patients with Chemo-naive mCRPC
  • 19:31 32.
    這些新藥國內已經上市了嗎? 健保的給付規定?怎麼用呢?
  • 19:41 33.
    Approved New Drugs for mCRPC
  • 20:35 34.
    Docetaxel : 健保規定
  • 20:53 35.
    Abiraterone : 健保規定
  • 21:39 36.
    Docetaxel的副作用
  • 22:52 37.
    Abiraterone(澤珂)的建議劑量及服藥方式
  • 23:24 38.
    Hormone Concentration After Abiraterone Acetate
  • 24:03 39.
    Hormone Concentration After Abiraterone Acetate + Dexamethasone
  • 24:33 40.
    Abiraterone的副作用
  • 25:12 41.
    臨床上如何選擇適合的mCRPC藥物?
  • 25:17 42.
    Slide 38
  • 26:13 43.
    Index Patient 3: Symptomatic mCRPC with good performance status and no prior docetaxel chemotherapy(有症狀,身體狀況良好,未接受過化療)
  • 26:46 44.
    Slide 40
  • 26:47 45.
    Index Patient 5: (Symptomatic) mCRPC with good performance status and prior docetaxel chemotherapy(有症狀,身體狀況良好,有接受過化療)
  • 27:30 46.
    Slide 42
  • 27:33 47.
    Index Patient 2: Asymptomatic or minimally-symptomatic mCRPC without prior docetaxel chemo(沒有症狀,身體狀況良好,沒有接受過化療)
  • 28:20 48.
    Proposed Decision Tree forAsymptomatic mCRPC (Clinical factor)
  • 29:16 49.
    Slide 45
  • 29:53 50.
    Slide 46
  • 30:22 51.
    Slide 47
  • 30:35 52.
    Common Drug Combination in mCRPC
  • 31:52 53.
    結論
  • 33:49 54.
    結論
  • 索引
  • 筆記
  • 討論
  • 全螢幕
Sequential and Combination Therapy for mCRPC – What Do We Have and How Do We Apply?
長度: 35:51, 瀏覽: 683, 最近修訂: 2017-05-19
    • 00:00 1.
      Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
    • 00:56 2.
      Sequential and Combination Therapy for mCRPC : What Do We Have and How Do We Apply?
    • 01:01 3.
      什麼是mCRPC? 和HRPC有何不同?
    • 01:20 4.
      HRPC versus CRPC
    • 02:23 5.
      Prostate Cancer Disease Stages<br />
    • 03:15 6.
      去勢療法出現抗性的攝護腺癌(CRPC)
    • 03:37 7.
      去勢療法出現抗性的攝護腺癌(CRPC)
    • 04:26 8.
      Molecular States Framework for AR Activation in Prostate Cancer
    • 04:49 9.
      Molecular States Framework for AR Activation in Prostate Cancer
    • 05:34 10.
      對於mCRPC,目前有哪些新藥?作用機轉為何?
    • 05:49 11.
      Approved New Drugs for mCRPC
    • 06:39 12.
      Approved New Drugs for mCRPC
    • 07:02 13.
      1966年諾貝爾醫學獎得主
    • 07:21 14.
      傳統上賀爾蒙治療的策略
    • 08:22 15.
      mCRPC病人賀爾蒙治療的策略
    • 09:07 16.
      正常情況下雄性素分泌的比例
    • 09:23 17.
      去勢男性雄性素分泌的情形
    • 09:52 18.
      Sites of Action by Androgen Biosynthesis Inhibitors
    • 10:34 19.
      <br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
    • 10:39 20.
      <br />Enzalutamide an AR signalling inhibitor: targets multiple steps in the (AR) signaling pathway<br />
    • 11:18 21.
      Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
    • 11:22 22.
      Taxane-based Chemotherapy Acts on Microtubules and AR Signaling
    • 12:35 23.
      Radium-223 Is a Unique α-Emitter
    • 13:05 24.
      [TITLE]
    • 14:14 25.
      Principle of Sipuleucel-T
    • 15:40 26.
      這些新藥能延長生命嗎? 能減輕痛苦嗎?
    • 15:52 27.
      Androgen-Deprivation Therapy雄性素去除療法:Continuous androgen deprivation (pharmaceutical or surgical) should be continued indefinitely regardless of additional therapies(Therapies in Addition to Androgen-Deprivation Therapy)Therapies with demonstrated survival
    • 16:41 28.
      Therapies with demonstrated survival benefit and unclear quality-of-life benefit可延長存活期:Sipuleucel-T in asymptomatic or minimally symptomatic p’tCabazitaxel in p’t progressed after docetaxelTherapies with quality-of-life benefit without demonstrated surviv
    • 17:47 29.
      Therapies without demonstrated survival or quality-of-life benefit過去臨床試驗證實無效者:BevacizumabEstramustineSunitinibPalliative Care Services緩和醫療Palliative care should be offered to all patients, particularly to those exhibiting symptoms or quality-of-life (QOL)
    • 18:27 30.
      New Drugs for Patient with mCRPC after Docetaxel
    • 19:08 31.
      New Drugs for Patients with Chemo-naive mCRPC
    • 19:31 32.
      這些新藥國內已經上市了嗎? 健保的給付規定?怎麼用呢?
    • 19:41 33.
      Approved New Drugs for mCRPC
    • 20:35 34.
      Docetaxel : 健保規定
    • 20:53 35.
      Abiraterone : 健保規定
    • 21:39 36.
      Docetaxel的副作用
    • 22:52 37.
      Abiraterone(澤珂)的建議劑量及服藥方式
    • 23:24 38.
      Hormone Concentration After Abiraterone Acetate
    • 24:03 39.
      Hormone Concentration After Abiraterone Acetate + Dexamethasone
    • 24:33 40.
      Abiraterone的副作用
    • 25:12 41.
      臨床上如何選擇適合的mCRPC藥物?
    • 25:17 42.
      Slide 38
    • 26:13 43.
      Index Patient 3: Symptomatic mCRPC with good performance status and no prior docetaxel chemotherapy(有症狀,身體狀況良好,未接受過化療)
    • 26:46 44.
      Slide 40
    • 26:47 45.
      Index Patient 5: (Symptomatic) mCRPC with good performance status and prior docetaxel chemotherapy(有症狀,身體狀況良好,有接受過化療)
    • 27:30 46.
      Slide 42
    • 27:33 47.
      Index Patient 2: Asymptomatic or minimally-symptomatic mCRPC without prior docetaxel chemo(沒有症狀,身體狀況良好,沒有接受過化療)
    • 28:20 48.
      Proposed Decision Tree forAsymptomatic mCRPC (Clinical factor)
    • 29:16 49.
      Slide 45
    • 29:53 50.
      Slide 46
    • 30:22 51.
      Slide 47
    • 30:35 52.
      Common Drug Combination in mCRPC
    • 31:52 53.
      結論
    • 33:49 54.
      結論
    位置
    資料夾名稱
    2015臺大攝護祭-醫藥護人員場
    發表人
    系統管理者
    單位
    泌尿部
    建立
    2017-05-19 16:58:15
    最近修訂
    2017-05-19 19:05:49
    長度
    35:51